The Indianapolis Colts announced some positive news ahead of the Week 16 matchup against the San Francisco 49ers.

The Colts have an 3% chance of making the playoffs, according to the New York Times playoff simulator, after Sunday's 4 p.m. games. So who should Colts fans be rooting for today?

Tonight’s week 16 MNF game features two teams heading in opposite directions. In the first half of the season, the 49ers dealt with key injuries on offense, started slowly, but have since been one of the hottest teams in the league.

With help from their Football Power Index tool, ESPN simulated the remainder of the 2025 season for the Indianapolis Colts. So how did things turn out? What the FPI model does is run thousands of simulations. For this exercise, Seth Walder selected just one of those simulations.

With three games left to play, the Indianapolis Colts must unleash a quarterback duo that can fully unlock the offense.

With Philip Rivers returning to the NFL, one key part of his Indianapolis Colts contract is a reset of his health insurance from the league, which was set to expire.

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Week 17 features critical matchups with the NFL playoffs approaching. Here are the odds, spreads and totals for every game.