A research team has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy. This ...

Autophagy a self-eating process where the body’s cells recycle their own damaged components to maintain health Our experts ...

In Japan, cancer has been the leading cause of death since 1981. At present, surgery, chemotherapy, and radiotherapy are the main treatment options. However, these treatments considerably reduce ...

A new study sheds light on how autophagy, the body's process for removing damaged cell parts, when impaired, can play a role in causing heart failure. The research team led by Dr. E. Dale Abel, chair ...

Autophagy, the cell’s essential 'housekeeping' process, involves degrading and recycling damaged organelles, proteins, and other components to prevent clutter. This vital mechanism, found in all life ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

Does fasting guarantee weight loss? Is longer fasting always healthier? Can fasting detox the body or cure lifestyle diseases? An internal medicine expert busts common fasting myths many Indians still ...

Upon autophagy induction, ZDHHC13 is recruited to autophagosome formation sites together with ATG9A. ULK1 is palmitoylated at Cys 927 and Cys 1003 residues by ZDHHC13, and the ULK1 complex are ...