AlphaFold can predict these structures without running experiments. In July 2021, researchers gained access to hundreds of thousands of these AI-predicted structures virtually overnight. Yet, to date, ...

The protein 'MIPS' changes its internal structure when it becomes active. Its disordered active centre becomes a defined structure with special functions. The protein plays a key role in the ...

Efforts to unlock the mysteries of proteins, building blocks of life, have earned three scientists the 2024 Nobel Prize in chemistry. The prize goes to David Baker “for computational protein design,” ...

FGF basic is a member of the FGF family, which includes at least 23 related mitogenic proteins sharing 35–60% amino acid conservation. Unlike most other FGFs, FGF acidic and FGF basic lack signal ...

In the wee hours of an October morning, David Baker, a protein biologist at the University of Washington (UW), received the most-awaited phone call in a scientist’s career. Halfway around the world, ...

Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...