Despite the tremendous efforts of researchers studying bone remodeling for more than 50 years, the intrinsic spatial, biomolecular, and mechanotransduction complexities in bone remodeling continue to ...

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts. An ...

During the post-translational methylation of arginine residues within proteins and proteolysis, asymmetric demethylation (ADMA) is released into the cytoplasm 1. ADMA has been generally implicated as ...

Osteoblasts act in a group to make bone over the course of several months. However, how osteoblasts cooperate with each other in vivo is still unknown. Now, researchers at Osaka University established ...

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis. NELL2 promotes ...