How do we find out which protein works in a particular DNA repair pathway? We know that if a DNA repair gene is mutated, cells become more sensitive to DNA damaging agents. Researchers in the 1960s ...

Insights could not only pave the way for new treatment strategies for genetic disorders, cancer and neurodegenerative diseases, but also enhance gene-editing technologies.

Zhi “Zack” Zheng is a member of molecular biologist Scott Keeney's lab. Zhi “Zack” Zheng, who is scheduled to receive his PhD from the Gerstner Sloan Kettering Graduate School of Biomedical Sciences ...

A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...

DNA polymerase θ (POLθ) is a specialized, error-prone DNA polymerase that promotes the repair of DNA double-strand breaks through theta-mediated end joining (TMEJ), an alternative pathway that ...

Efficacy and safety data from Ph1b, dose optimization trial of two doses of TH1902 (sudocetaxel zendusortide), a novel SORT1-targeting peptide drug conjugate (PDC), administered weekly vs q3weekly in ...

BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...

While researchers have long appreciated the enormous potential of genome editing to treat disease, applications of these technologies in humans have historically been limited by safety concerns. Even ...

Study establishes for the first time that defective DNA repair may be the major driver of several clinical features associated with a subset of patients with 22q11.2 distal deletion syndrome ...

A new mouse study found that unrepaired DNA-protein crosslinks activate inflammatory signaling pathways that trigger early aging disorders.

Broken String Biosciences launched an early access program (EAP) through which select developers of gene edited therapeutics will be able to use Broken String’s INDUCE-seq ® technology in their own ...