Matchmaking between ketones and olefins has never been easy. Although ketones readily pair up with many reagents, thanks to their ability to deprotonate and form nucleophilic enolates, olefins ...
The lack of methods available for installing functionalities or structural motifs during chemical synthesis can at first be frustrating. However, retrosynthetic analysis 1, a way of viewing the target ...
The creation of all-carbon quaternary stereocentres represents one of the most demanding objectives in modern synthetic chemistry. Such contorted carbon frameworks are ubiquitous in natural products, ...
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