Nature

Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships

Advancing spatially resolved in vivo functional genomes will link complex genetic alterations prevalent in cancer to critical disease phenotypes within tumour ecosystems. To this end, we developed ...
insider.si.edu

Statistical theory and methods for evolutionary genomics / Xun Gu

1. Basics in molecular evolution -- 2. Basics in bioinformatics and statistics -- 3. Functional divergence after gene duplication: statistical modeling -- 4. Functional divergence after gene ...
Nature

Actionability classification of variants of unknown significance correlates with functional effect

In this study, we sought to determine how often VUS in actionable genes are oncogenic using a functional genomics platform that utilizes two cell lines, MCF10A and BaF3, to measure an alteration’s ...
GEN

AstraZeneca, University of Cambridge Expand Functional Genomics Collaboration

Functional genomics studies investigate genetic changes that contribute to disease development and progression with an eye toward making better therapies and diagnostics. In a new laboratory at the ...