Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more ...

Preclinical results indicate new approach could be a way to deliver treatment directly to tumors at higher doses, while reducing side effects in healthy tissue.

Researchers developed a chimeric cancer drug that links an Aurora kinase A inhibitor to a tumor-targeting molecule. In ...

Many cancers involve upregulation of Aurora kinase B, which helps deregulate normal cell cycling to drive tumor proliferation. The kinase should therefore be a good therapeutic target, yet no ...

Comparative efficacy of cabozantinib or lenvatinib following atezolizumab plus bevacizumzb in patients with advanced hepatocellular cancer. Development and validation of a prognostic risk score for ...

Molecular glues are small, monovalent molecules that reshape an E3 ubiquitin ligase (E3) surface to promote a new protein-protein interaction with a target, triggering ubiquitination and removal by ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.