Increasing evidence suggests that apoptosis may be the mechanism underlying cell death in selective loss of nigral dopaminergic neurons in Parkinson's disease (PD). Previous studies strongly suggested ...

Until five years ago, scientists investigating Parkinson’s disease were frustrated in their attempts to unravel the biochemical mechanism of this debilitating disease. Lacking an animal model, they ...

In a mouse model of early Parkinson's disease (PD), animals displayed movement deficits, loss of tyrosine-hydroxylase (TH)-positive fibers in the striatum, and astro-gliosis and micro-gliosis in the ...

Department of Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), College of Medicine, Rootstown, OH School of Biomedical Sciences, Kent State University, Kent, OH Environmental ...