Alzheimer’s disease (AD) is the most common cause of dementia, which is characterized by amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. Age is one of the strongest risk factors for ...

The typical signs and symptoms of idiopathic NPH are shown. In a retrospective study involving 418 patients with shunt-responsive idiopathic NPH, 96% of the patients had gait difficulty, 76% had ...

The kinetics of amyloid beta turnover within human brain is still poorly understood. We previously found a dramatic decline in the turnover of Aβ peptides in normal aging. It was not known if brain ...

Cerebrospinal fluid (CSF) and other biomarkers differ for individuals with Alzheimer disease and cognitively normal controls, with the estimated times of divergence varying from 18 to six years before ...

The brain floats in a sea of fluid that cushions it against injury, supplies it with nutrients and carries away waste. Disruptions to the normal ebb and flow of the fluid have been linked to ...

Cerebrospinal fluid (CSF) is a type of clear liquid that surrounds, protects, and cushions your brain and spinal cord from possible injuries. The fluid is held in place by the dura mater, a dense ...

Idiopathic intracranial hypertension, also called pseudotumor cerebri, refers to elevated cerebrospinal fluid (CSF) pressure that develops most often in women of reproductive age with obesity, causing ...

Hydrocephalus, commonly referred to as "water on the brain," is a dangerous and potentially deadly condition that can harm the brain. For more than a century, physicians have believed that the buildup ...

Few scientists doubt that backed-up clearance of detritus from the brain correlates with accumulation of amyloid plaques and neurofibrillary tangles. But which comes first? Data presented at the 9th ...

CSF oligoclonal bands is a test ordered by physicians when serious health concerns related to your central nervous system arise. Here’s what you need to know about it. If your physician suspects ...

Meta-analysis showed that the level of sAPPα in the cerebrospinal fluid of people with normal pressure hydrocephalus is about half that of people with Alzheimer's disease (effect size = 0.439, p ...