Jim, a 57-year-old Boston businessman, climbs up on an examining room table at Brigham and Women's Hospital for a procedure that's high on most men's list of dreads: a prostate biopsy. A doctor will ...

Employing MRI-targeted biopsy instead of systematic biopsy reduces overdiagnosis of low-grade prostate cancer by more than half, although diagnoses may be delayed among a small minority of patients ...

An elevated PSA reading has long put men in an uncomfortable position: it signals possible prostate cancer, but it is ...

Screening for prostate cancer is burdened by a high rate of overdiagnosis. The most appropriate algorithm for population-based screening is unknown. We invited 37,887 men who were 50 to 60 years of ...

Elevated PSA with a negative biopsy What is the next step in the treatment of a patient who has a prostate-specific antigen (PSA) level between 4 and 10 ng/mL and a negative biopsy?— Jack W. Spitzberg ...

Alternatives to prostate biopsies include enzyme tests to assess the need for further screening, monitoring PSA levels through watchful waiting, and MRI scans for detailed prostate imaging. Enzyme ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

In a study involving more than 11,000 men enrolled in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial, about one quarter of elevated prostate-specific antigen (PSA) results ...

For many men, a prostate cancer scare starts with one number. A PSA result comes back high, and ...

If your doctor suspects that you have prostate cancer, they may advise you to undergo a prostate biopsy procedure. A biopsy is a standard cancer screening test that involves the careful removal of ...