ascopubs.org

Paired matched normal sequencing to accurately identify somatic clonal hematopoiesis mutations (CHm) in solid tumor tissue and plasma specimens.

ctDNA as a biomarker in phase II study of tepotinib in advanced solid cancers with MET exon 14 skipping mutation or amplification (KCSG AL19-17). Characterization of molecular response and progression ...
ascopubs.org

Exome Sequencing of Paired Colorectal Carcinomas and Synchronous Liver Metastases for Prognosis and Therapy Prediction

TP53 Gain-of-Function and Non–Gain-of-Function Mutations Are Associated With Differential Prognosis in Advanced Pancreatic Ductal Adenocarcinoma The study used whole-exome sequencing of tumor sample ...
Business Wire

Ambry Genetics Publishes 43,000 Patient Study Showing Combined RNA and DNA Analysis Identifies Patients Who Are High-Risk for Cancer but Would Have Been Missed by DNA Testing Alone

ALISO VIEJO, Calif.--(BUSINESS WIRE)--Ambry Genetics, a leader in clinical diagnostic testing and a subsidiary of REALM IDx, Inc., announced today the findings of a study that showed paired RNA and ...
Labroots

Concordance of targeted sequencing from circulating tumor DNA and paired tumor tissue

In this study, we evaluated the concordance of targeted sequencing results between paired ctDNA and tumor samples from early breast cancers scheduled for curative surgery with or without adjuvant ...
BioTechniques

Characterizing genomic and epigenomic variation between tumor–normal research samples using long nanopore sequencing reads

Genomic instability is characteristic of most cancers. To explore this, paired tumor–normal whole-genome sequencing can be used to gain deeper understanding of genomic and epigenomic variability in ...
News Medical

Can adding RNA sequencing to germline genetic testing improve accuracy and clinical sensitivity over time compared to DNA sequencing alone?

In a recent study published in the Journal of American Medical Association (JAMA) Oncology, researchers from California investigated the diagnostic outcomes of concurrent sequencing of ...
JSTOR Daily

Paired high-throughput, in situ imaging and high-throughput sequencing illuminate acantharian abundance and vertical distribution

Acantharians (supergroup Rhizaria) can be important contributors to surface primary production and to carbon flux to the deep sea, but are often underestimated because their delicate structures are ...
GEN

Recent Advances in NextGen Sequencing

Illumina just released new sequencing chemistry kits and complementary software for its Genome Analyzer system. These new products reportedly enable researchers to generate 40% more reads per run and ...