The American Journal of Managed Care

Recent Advances Raise Hopes of Better Addressing Richter Transformation

Richter transformation develops in 2%–10% of CLL cases, often with rapid clinical decline, limited chemotherapy efficacy, and ...
The American Journal of Managed Care

BTKis Show Promise in Richter Transformation, but More Data Are Needed

Acalabrutinib (Calquence; AstraZeneca) demonstrated a more modest ORR of 40% in a smaller 25-patient cohort, with median progression-free survival (PFS) of 3.2 months. While less robust than ...
BioWorld

Researchers link Bcor loss to Richter transformation of CLL through Notch1 activation

Richter transformation (RT) refers to the occurrence of an aggressive and treatment-resistant lymphoma that arises from the progression of chronic lymphocytic leukemia (CLL) and is associated with a ...
Morningstar

Genmab Announces New Data from Phase 1b/2 EPCORE® CLL-1 Highlighting Potential of Epcoritamab as Monotherapy and in Combination for Patients with Richter Transformation (RT)

Two-year epcoritamab monotherapy data demonstrate high complete response and encouraging survival rates in patients with Richter transformation (RT), highlighting its potential as a treatment option ...
Targeted Oncology

Navigating the Logistical and Clinical Hurdles of Richter Transformation

Targeted Oncology: The Richter transformation remains one of the most daunting diagnoses in hematology. Given your recent work with the BRUIN (NCT03740529)1 study, what are the red flags community ...
Targeted Oncology

The Paradox of Progress: Personalizing First-Line Therapy in CLL

Expert breaks down CLL frontline choices, IGHV and p53 risk, and what fits patient life. The treatment landscape for chronic ...