Although the integration of lentiviral vectors has proved to be safe in previous clinical studies of gene therapy, 11 two reports have described clonal expansions related to lentiviral vector ...

Journal in the field and provides all-inclusive access to the critical pillars of human gene therapy: research, methods, and clinical applications. Recent clinical trials utilizing high doses of adeno ...

Adeno-associated virus (AAV) vectors play a pivotal role in gene therapy, delivering therapeutic genes with high precision and safety. However, a significant challenge in the biomanufacturing of these ...

No vector-related safety concerns have been noted in any patient in the study who received gene-modified hematopoietic stem cells; specifically, no leukoproliferative or myelodysplastic complications, ...