Ok, so I've got a Windows 95 machine which tells me "Windows has detected a registry configuration error", and prompts me to boot into safemode at the boot menu. The problem is, it won't boot into ...
An unexpected way to relive the nostalgia of Windows 95 on Linux, but the experience comes with its own set of challenges.
I think it would depend on the motherboard. Some can make a USB drive appear as an INT 13 device, and I've seen some USB drivers for DOS.