Gut

Norepinephrine promotes tumour cell aggressiveness and NK cell ferroptosis via ADRB2 in intrahepatic cholangiocarcinoma with perineural invasion

Background Sympathetic signalling plays a critical role in the initiation and progression of various malignancies. However, ...
Gut

Tryptophan depletion generates hyper-reactive portal neutrophils in alcoholic liver disease

Background Neutrophils guarantee a prompt and robust host response to pathogens. Yet, overshooting neutrophil activation ...
Gut

Loss of sinusoidal endothelial identity: RAP1A at the crossroads of capillarisation and liver fibrosis

Liver fibrosis represents a serious worldwide health issue with a prevalence of around 5% in general populations.1 The most ...
gut.bmj

Targeting ADAR1-mediated RNA editing inhibits hepatic stellate cell activation and liver fibrosis by enhancing HSC-intrinsic innate immunity

Background The pathogenesis of liver fibrosis centres on the activation of hepatic stellate cells (HSCs). Adenosine-to-inosine RNA editing, primarily catalysed by adenosine deaminase acting on RNA1 ...
gut.bmj

Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells

3 Department of Experimental Medicine, Biotechnology and Molecular Biology section, Seconda Università di Napoli, Naples, Italy Correspondence to Professor Rosario Cuomo, Department of Clinical and ...
gut.bmj

Development of a disease specific questionnaire to measure health related quality of life in patients with chronic liver disease

Dr Z M Younossi, The Cleveland Clinic Foundation, Department of Gastroenterology, Desk S-40, 9500 Euclid Avenue, Cleveland, OH 44195, USA. BACKGROUND AND AIMS To develop and assess a disease specific ...
gut.bmj

Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up

Correspondence to Dr Simon PL Travis, Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford OX3 9DU, UK; simon.travis{at}ndm.ox.ac.uk Background Endoscopic mucosal healing is an ...
gut.bmj

Integrative proteogenomics maps multifactorial aetiology, progression and therapeutic vulnerabilities in gastric cancer

Background Gastric cancer, with disproportionately higher incidence in East Asia, arises from complex host–microbiome–environment interactions beyond Helicobacter pylori (HP) infection. However, the ...
gut.bmj

Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians

12 Liver Clinic, Toronto Western & General Hospital, University Health Network, Toronto, Ontario, Canada Correspondence to Professor H L A Janssen, University of Toronto & Erasmus University Rotterdam ...
gut.bmj

Inflammation of the gastro-oesophageal junction (carditis) in patients with symptomatic gastro-oesophageal reflux disease: a prospective study

Department of Medicine, Division of Digestive Diseases and Gastroenterology, UCLA Medical Centre and Beth Israel Deaconess Medical Centre, Los Angeles, California, USA Dr T Lembo, Beth Israel ...
gut.bmj

Infection rate and spontaneous seroreversion of anti-hepatitis C virus during the natural course of hepatitis C virus infection in the general population

1 Department of Virology, Istituto Superiore di Sanità, Rome, Italy 2 Department of Epidemiology, Istituto Superiore di Sanità, Rome, Italy Background: Hepatitis C virus (HCV) infection is common ...
gut.bmj

Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis

Background The relationship between delayed gastric emptying and upper GI symptoms (UGI Sx) is controversial. Objective To assess association between gastric emptying and UGI Sx, independent of ...