Once a drug target is identified, it often takes decades until a chemical compound is developed that can hit the bullseye and ...

The awards were made possible by ongoing support from the Blavatnik Family Foundation that aims to spur scientific ...

Immunotherapy has redefined cancer treatment, but not all patients experience the same benefit when treated. New research in mice identifies how gut bacteria alter the body’s response to a common form ...

If current guidelines for cholesterol and high blood pressure treatment remain unchanged, a newly unveiled heart risk calculator would render 16 million people ineligible for preventive therapy. Loss ...

A protein called STUB1 weakens the cancer-killing power of immune T cells by blocking key signals they need to attack tumors. Disabling STUB1 in lab experiments strengthened T cells’ response to the ...

Work described in this story was made possible in part by federal funding supported by taxpayers. At Harvard Medical School, the future of efforts like this — done in service to humanity — now hangs ...

Top row: In a mouse model of Alzheimer's disease, lithium deficiency (right) dramatically increased amyloid beta deposits in the brain compared with mice that had normal physiological levels of ...

This article is part of Harvard Medical School’s continuing coverage of COVID-19. A new study of more than 800,000 people has found that in the U.S., COVID “long haulers” were more likely to be older ...

Three key players share the story of how fundamental discoveries in the laboratory became a first-of-its-kind therapy that promises to have a monumental impact on sickle cell disease patients around ...

Many people with autism spectrum disorders also experience unusual gastrointestinal inflammation, but thus far scientists have not established whether and how those conditions might be linked. Now, ...

Over the past several years, scientists have generated intriguing insights suggesting that variations in gut microbiomes—the collections of bacteria and other microbes in our digestive systems—may ...