The Pediatric Research Equity Act was intended to promote the development and testing of prescription drugs for children. But its implementation has been constrained.

Post-thrombotic syndrome is common after deep-vein thrombosis and can cause severe symptoms involving the limbs that impair patients’ activity and quality of life. Endovascular therapy can ...

Celiac disease, a common autoimmune condition affecting approximately 1% of the population, can develop with exposure to gluten at any age. Diagnosis involves serologic testing, especially for IgA ...

It is regrettable that pulmonary embolism as a discrete cause of sudden cardiac arrest in athletes is not addressed by Lampert and Harmon’s recent review (Jan. 15 issue).1 In an ...

The parents of Terri Schiavo, a Florida woman who was in a persistent vegetative state, objected to her husband's decision to discontinue artificial nutrition, and a protracted legal battle ensued.

An 18-year-old man presented to the emergency department with generalized tonic–clonic seizures. MRI of the head showed numerous well-defined cystic lesions in the brain that were consistent with ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 2).

Owing to the fact that most thromboembolic complications that are attributed to atrial fibrillation originate in the left atrial appendage, 1 therapies targeting the anatomical structure that might ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 5).

To the Editor: The results of the randomized trial by Parienti et al. (Sept. 24 issue) 1 comparing insertion sites for central venous catheterization will help guide clinicians in their choice of ...

Health worker burnout, exacerbated by Covid-19, is not only about long hours. It’s about the fundamental disconnect between health workers and the mission to serve that motivates them.

A 70-year-old woman had a urinary catheter placed during hospitalization for an acute stroke. Ten days later, the urine appeared purple.