Calcitonin is a peptide hormone that in humans is produced by thyroid cells. This hormone is involved in the metabolism of calcium and phosphate and acts to reduce blood levels of calcium and inhibit ...
What we can learn from fish calcitonin and its receptor: Evolutionary insights and medical potential
In fish, multiple HBD of CTR and stable ɑ-helix of calcitonin contribute to the high binding affinity and slow dissociation, thus triggering prolonged AC/cAMP signaling. In humans, RAMP dependent ...
Medullary thyroid carcinoma (MTC) in MEN2B syndrome is associated with germline RET mutation. Patients harboring de novo mutations are usually diagnosed at more advanced disease stages. We present a ...
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