When it comes to the differences between the 6.7L Cummins and the 6.7L Power Stroke diesel engines, the former is more reliable while the latter is stronger.
The Ford 428 Cobra Jet was a capable engine in vehicles from 1968 to 1970. Although it didn't find much use later, it was active in a wide number of models.
What happens when you take an industrial engine and drop it in a truck? You get a pickup that you'll pass on to your grandkids.