Panelists discuss how immunoglobulin A (IgA) nephropathy develops through a complex 4-hit cascade involving aberrant IgA1 glycosylation, anti-glycan antibody formation, immune complex deposition, and ...

Analysis of Alzheimer’s brains revealed age-related accumulation of cancer driver mutations, particularly in microglia. These ...

Fatty liver diseases (FLD) have become a significant health concern worldwide, affecting millions. The two most common types of FLD are non-alcoholic fatty liver disease (NAFLD) and ...

Like all forms of cancer, lung cancer is defined by uncontrolled cell division caused by loss of physiological tissue homeostasis and failure of apoptotic cell death mechanisms. Aberrant cell ...

Despite the long history of psoriasis and psoriatic arthritis (PsA), until recently, little had been known of their underlying genetics and pathogenesis. Without this knowledge, rational clinical ...

Leucine-rich repeat-containing 8A (LRRC8A) is a ubiquitously expressed transmembrane protein that functions as the essential component of volume-regulated anion channels (VRACs). These channels are ...

FROM the impact of epidemics on the rise and fall of empires to the part played by the Black Death in hastening the transition from a feudal, religious society to a capitalist, secular one, humankind ...