Apathy in people with Huntington’s disease (HD) isn’t just a lack of interest or motivation, it is a loss of drive, initiative, and emotional responsiveness that affects not only what the person with ...

HDBuzz has always been free to read, and we intend to keep it that way. But free to read doesn’t mean free to run. As an ...

If CRISPR stays active too long, it could cut unintended parts of the genome. To reduce this risk, the researchers designed a self-inactivating CRISPR system. This means that CRISPR edits the gene and ...

Artificial Intelligence, or AI, has become an everyday feature of the world we live in. Internet browsers have an ‘AI mode’ and even our refrigerators and vacuum cleaners now include AI features!

Anew study using precise gene editing in a Huntington’s disease (HD) mouse model provides evidence that a small fragment of the huntingtin (HTT) protein, called HTT1a, is a central driver of HD. By ...

In August 2025, an occupational therapist named Alex Fisher walked to the furthest edge of Barranquitas, Venezuela, past rutted tracks and reed-filled canals, through 102°F / 39°C heat, to assess a ...

Scientists used cells from a person with Huntington’s disease (HD) to test whether lowering the levels of DNA repair genes can slow the growth of the nefarious CAG repeat. In these human cells grown ...

Huntington’s disease (HD) is caused by a repeated stretch of the genetic letters C-A-G within the huntingtin (HTT) gene above a critical number. If the repeats exceed 40, then signs and symptoms of HD ...

A new Huntington’s disease (HD) clinical trial has reached an important milestone: the first participants have now been dosed in POINT-HD, a Phase 1 study testing a new, selective huntingtin-lowering ...

Welcome back to the HDBuzz monthly research roundup! November was a busy month, with new developments in everything from gene therapy and stem cells to DNA repair, genetic modifiers, and protein ...

SOM3355 is an investigational therapy aimed at managing multiple symptoms of Huntington’s disease (HD) and recently crossed two key regulatory milestones. In September, the European Medicines Agency ...