Gut

Norepinephrine promotes tumour cell aggressiveness and NK cell ferroptosis via ADRB2 in intrahepatic cholangiocarcinoma with perineural invasion

Background Sympathetic signalling plays a critical role in the initiation and progression of various malignancies. However, ...
Gut

Tryptophan depletion generates hyper-reactive portal neutrophils in alcoholic liver disease

Background Neutrophils guarantee a prompt and robust host response to pathogens. Yet, overshooting neutrophil activation ...
Gut

Loss of sinusoidal endothelial identity: RAP1A at the crossroads of capillarisation and liver fibrosis

Liver fibrosis represents a serious worldwide health issue with a prevalence of around 5% in general populations.1 The most ...
gut.bmj

Targeting ADAR1-mediated RNA editing inhibits hepatic stellate cell activation and liver fibrosis by enhancing HSC-intrinsic innate immunity

Background The pathogenesis of liver fibrosis centres on the activation of hepatic stellate cells (HSCs). Adenosine-to-inosine RNA editing, primarily catalysed by adenosine deaminase acting on RNA1 ...
gut.bmj

Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats

1 Gastroenterology Unit, Université Catholique de Louvain (UCL), Brussels, Belgium 2 Pathology Unit, Université Catholique de Louvain (UCL), Brussels, Belgium Correspondence to: Professor I Leclercq ...
gut.bmj

Development of a disease specific questionnaire to measure health related quality of life in patients with chronic liver disease

Dr Z M Younossi, The Cleveland Clinic Foundation, Department of Gastroenterology, Desk S-40, 9500 Euclid Avenue, Cleveland, OH 44195, USA. BACKGROUND AND AIMS To develop and assess a disease specific ...
gut.bmj

Inflammation of the gastro-oesophageal junction (carditis) in patients with symptomatic gastro-oesophageal reflux disease: a prospective study

Department of Medicine, Division of Digestive Diseases and Gastroenterology, UCLA Medical Centre and Beth Israel Deaconess Medical Centre, Los Angeles, California, USA Dr T Lembo, Beth Israel ...
gut.bmj

OTH-005 Prospective multi-site audit of acute upper gastrointestinal bleeding delivered across multiple regions by trainee-led networks

1 on behalf of GARNet (Gastroenterology Audit and Research Network, East Midlands) 2 on behalf of WMRIG (West Midlands Research in Gastroenterology Group) 3 on behalf of GasTRIN NoW (Gastroenterology ...
gut.bmj

Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians

12 Liver Clinic, Toronto Western & General Hospital, University Health Network, Toronto, Ontario, Canada Correspondence to Professor H L A Janssen, University of Toronto & Erasmus University Rotterdam ...
gut.bmj

Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells

3 Department of Experimental Medicine, Biotechnology and Molecular Biology section, Seconda Università di Napoli, Naples, Italy Correspondence to Professor Rosario Cuomo, Department of Clinical and ...
gut.bmj

Integrative proteogenomics maps multifactorial aetiology, progression and therapeutic vulnerabilities in gastric cancer

Background Gastric cancer, with disproportionately higher incidence in East Asia, arises from complex host–microbiome–environment interactions beyond Helicobacter pylori (HP) infection. However, the ...
gut.bmj

IDDF2023-ABS-0235 The Drp1 inhibitor mdivi1 improves liver steatosis in nonalcoholic fatty liver disease in mice by regulating JNK/MFF pathway

Background Mitochondrial fission has been important and implicated in the pathogenesis of the nonalcoholic fatty liver disease (NAFLD) but poorly defined mechanisms. Mitochondrial division inhibitor1 ...