BACKGROUND There is increasing evidence that reflux of bile plays a part in the pathogenesis of Barrett's oesophagus. Bile injury to the gastric mucosa results in a “chemical” gastritis in which ...

The intestine and its immune system have evolved to meet the extraordinary task of maintaining tolerance to the largest, most complex and diverse microbial commensal habitat, while meticulously ...

Background Adenoma recurrence after polypectomy is a critical clinical concern, as it directly impacts the surveillance interval and the risk of developing interval colorectal cancer (CRC).

Introduction Azathioprine is frequently prescribed for the management of inflammatory bowel disease (IBD), however there is considerable variation in how it is initiated. It remains common practice to ...

Oesophageal dilators or bougies have been used since the Middle Ages. Early bougies were made of natural materials and were used to disimpact food boluses by pushing them “blindly” into the stomach.

BACKGROUND K- ras mutation is one of the first genetic alterations in classical colorectal carcinogenesis. AIMS To investigate the role of K- ras mutations in carcinogenesis, in long standing ...

Background —Life stress contributes to symptom onset and exacerbation in the majority of patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD); research evidence is conflicting, ...

Objective Gut microbiota alterations are associated with obesity. Early exposure to medications, including acid suppressants and antibiotics, can alter gut biota and may increase the likelihood of ...

Background Lumen-apposing metal stents (LAMSs) are increasingly used for the endoscopic management of pancreatic fluid ...

Portal hypertension is the major complication of chronic liver disease and is associated with reduced survival.1Pharmacological treatment is based on the premise that a sustained reduction in portal ...

Background: Inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD) may have a high prevalence of rectal sparing, backwash ileitis, and colorectal neoplasia. Aims: To ...