The DISC5 Awards will support exploratory and innovative foundational research led by pairs of interdisciplinary investigators applying a range of technologies and approaches to address fundamental ...

250+ Clinical Trials: Hosted at Alpha Clinics for CIRM funded and other research. 2000+ Patients Enrolled: Pioneers who participated in a clinical trial at an Alpha Clinic. 40+ Diseases & Conditions: ...

CIRM is supporting a network of 11 Shared Resources Laboratories (SRLs) for Stem Cell-Based Modeling, an important component of CIRM’s Infrastructure Program designed to address challenges that hinder ...

The California Cell and Gene Therapy Manufacturing Network was established by CIRM to expand the manufacturing capabilities necessary to bring stem cell and gene therapies from foundational research ...

CIRM Disclaimer: The information in the table has been collected by CIRM to help CIRM awardees accelerate the development of pluripotent stem cell-derived therapeutics. The information is intended to ...

心肌细胞（CM）是不可再生的。 自我更新的多能人类胚胎干细胞 (hESC) 可以分化为用于细胞疗法的 CM。 在成人CM中，Ca (2+)诱导的Ca (2+)通过兰尼碱受体 (RyR)从肌浆网 (SR)释放是兴奋-收缩耦合的关键。 因此，hESC 衍生的 CM 需要具有适当的 Ca (2+) 处理特性，才能与受体心脏成功进行功能整合。 在这里 ...

心肌细胞（CM）是不可再生的。 自我更新的多能人类胚胎干细胞 (hESC) 可以分化为用于细胞疗法的 CM。 我们最近报道，Ca (2+) 处理对于 hESC 衍生的 CM (hESC-CM) 的兴奋-收缩耦合至关重要，具有功能性但不成熟。 胞质Ca (2+)瞬时幅度较小、动力学较慢和肌浆网 (SR)Ca (2+)含量减少等不成熟特性可归因于特定Ca ...

许多免疫缺陷是由于胸腺功能丧失所致，胸腺是 T 淋巴细胞的来源，T 淋巴细胞是免疫系统保护我们的身体免受感染所需的白细胞。胸腺上皮细胞 (TEC) 是皮肤样细胞胸腺中允许人体产生 T 淋巴细胞、TEC 的细胞会因癌症化疗和放射、HIV 感染和衰老而受损，导致免疫功能丧失。 在 CIRM 的资助下，我们 ...

La maladie de Huntington (HD) est une maladie neurodégénérative provoquée par des répétitions CAG étendues dans le gène huntingtin qui altèrent l'homéostasie cellulaire, en particulier dans le ...

Research Objective Approximately 20,000 babies are born annually with kidney disease; the long-term outcome is poor. These studies address new ways to develop mini-kidney structures for ...

Traumatic brain injuries (TBI) are the seventh leading cause of disability globally with 48.99 million prevalent cases and 7.08 million years lived with diability. Approximately 80 % of TBI patients ...

Fundación – Proyectos de investigación en etapa de descubrimiento Universidad de California en Los Ángeles Superación de barreras para la terapia génica con células madre de las vías respiratorias ...