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Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers.

Marty G Yang, Hannah J Richter, Simai Wang, Colin P McNally, Nicole Harris, Simaron Dhillon, Michela Maresca, Elzo de Wit, Holger Willenbring, Jacquelyn Maher, Hani Goodarzi, Vijay Ramani We present a ...
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Stem Cell-Based Cartilage Tissue Regeneration

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Gene Therapy for Alpha-1 Anti-Trypsin Deficiency

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4D Molecular Therapeutics, Inc.

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Protocol to study ductal progenitor-like cells from the adult human pancreas using 3D suspension and methylcellulose-based culture systems.

The pancreas is comprised of two compartments, the exocrine and endocrine. The exocrine acinar cells produces and secreted digestive enzymes that are carried by ductal cells to the duodenum, whereas ...
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RNA Modifications in Cancer Stem Cell Biology.

Cell function can be largely defined by its gene expression that regulates production of functional proteins. Different layers of mechanisms control gene expression to ensure correct protein synthesis ...
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Phase I/II Clinical Trial for CMT4J

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Clinical Development of ETX101, a Gene Regulation Therapy for SCN1A+ Dravet Syndrome

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Astroglia’s role in synchronized spontaneous neuronal activity: from physiology to pathology.

The brain depends on a careful balance between signals that excite neurons and those that calm them down. When this balance is lost and neurons become overly active, it can lead to serious ...
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Demographics, Prevalence, and Characteristics of Limbal Stem Cell Deficiency in Southern California.

Limbal stem cell deficiency (LSCD) is a potentially blinding disease characterized by the loss of the stem cell population. The purpose of this publication is to report the prevalence, incidence and ...
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Androgenetic alopecia.

Yingzi Liu, Antonella Tosti, Etienne C E Wang, Stefanie Heilmann-Heimbach, Crystal Aguh, Francisco Jimenez, Sung-Jan Lin, Ohsang Kwon, Maksim V Plikus Androgenetic alopecia (AGA) is a condition of ...
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Complementary biomolecular coassemblies direct energy transport for cardiac photostimulators.

Ze-Fan Yao, Sujeung Lim, Yuyao Kuang, Emil M Lundqvist, Natalie Celt, Caleb O Chung, Kathryn K Lee, Krystal Nguyen, Lanie Le, Sheng Wei Tang, Griffin M Milligan, Phillip Kohl, Tarunya Rao Sudarshan, ...