The Pediatric Research Equity Act was intended to promote the development and testing of prescription drugs for children. But its implementation has been constrained.

A 27-year-old woman presented with a 2-week history of joint pain, fever, sore throat, and a nonpruritic rash that worsened during fever. Laboratory tests showed an elevated ESR and elevated ...

It is regrettable that pulmonary embolism as a discrete cause of sudden cardiac arrest in athletes is not addressed by Lampert and Harmon’s recent review (Jan. 15 issue).1 In an ...

Post-thrombotic syndrome is common after deep-vein thrombosis and can cause severe symptoms involving the limbs that impair patients’ activity and quality of life. Endovascular therapy can ...

Celiac disease, a common autoimmune condition affecting approximately 1% of the population, can develop with exposure to gluten at any age. Diagnosis involves serologic testing, especially for IgA ...

Explore the current issue of The New England Journal of Medicine (Vol. 394 No. 13).

Douglas Opel is a professor in the Department of Pediatrics at the University of Washington School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal.

In a 10-patient feasibility study, heart digital twins were used to guide VT ablation. Afterward, VT was noninducible in all patients; at a mean follow-up of 13 months, 8 patients were free of ...

This feature about acute liver failure on the background of alcohol-associated cirrhosis offers a case vignette accompanied by two essays, one recommending liver transplantation and the other ...

Transfusion-dependent β-thalassemia and sickle cell disease, both characterized by defective hemoglobin synthesis, are the most common monogenic diseases worldwide. Each year, approximately 60,000 ...

In this prospective, open-label, noninferiority trial with a prespecified sequential testing strategy for superiority and blinded outcome adjudication, we randomly assigned patients with infrainguinal ...

Assessing intermediate coronary lesions with an intracoronary pressure wire improves clinical outcomes in patients undergoing cardiac catheterization and percutaneous coronary intervention (PCI).