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Lab results are only as useful as the way they’re interpreted. Tryptase is a perfect example. Most labs report a single reference range, often labeling anything under a certain number as “normal.” But when you look closer at the research, tryptase levels vary by age, population, and percentile. What may fall within a standard reference range may not be optimal for a specific patient sitting in front of me. For patients with mast cell reactivity, these nuances matter. Interpreting labs through an
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When I diagnose Mast Cell Activation Syndrome (MCAS), I use the Consensus 2 criteria. This method moves beyond the traditional tryptase-level criteria of Consensus 1, and focuses instead on symptom charts, response to treatment and specific lab tests. I’ve found this method to work impeccably. Many practitioners are not aware of mast cell activation syndrome and the complexity of how it can present, or either continue to use the outdated Consensus 1 approach or, worse, revert to an understanding
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