Let's look at oral estrogen and the "first pass effect of the liver." This impacts dosing - and blood clot risk. It's complicated, but learn with me on Transgender Medicine Made Simple. Linda Gromko MD | Linda Gromko
Let's look at oral estrogen and the "first pass effect of the liver." Thi…
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Video: First Pass Effect
Video: First Pass Effect
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First-pass metabolism by liverWhich of the following examples... | Filo
First-pass metabolism by liverWhich of the following examples... | Filo
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💊 يعني إيه First-Pass Effect؟ هو إن جزء كبير من الدواء بيتكسر في الكبد قبل ما يوصل للدم، وده بيقلّل جدًا من كمية الدواء اللي بتتوفر فعليًا للجسم — أو بمعنى تاني ↓ كل ما زاد الـ First-pass effect ↓ قلت الـ Bioavailability 💡 🩺 مثال: دواء زي Propranolol بيتكسر بنسبة كبيرة في الكبد أول ما يتاخد فموي، علشان كده بيحتاج جرعات أعلى أو طريقة إعطاء مختلفة. ✅ بعض الطرق بتتجنب الـ First-pass metabolism زي: Sublingual – Transdermal – Intravenous – Rectal – Inhalation 🎓 جزء من شرح كورس مقدمة الفارماكولوجي
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💊 يعني إيه First-Pass Effect؟ هو إن جزء كبير من الدواء بيتكسر في الكبد قبل ما يوصل للدم، وده بيقلّ…
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